Researchers discover how three-dimensional organization of the genome regulates cell differentiation

A new study from the University of Minnesota Medical School clarifies how the three-dimensional organization of the genome is regulated at the onset of skeletal muscle formation. Although the DNA sequence of the genome is a linear code, like a long sentence, the actual DNA molecule twists and folds in 3-D space, with some sequences that are distant from each other in sequence being physically close to each other in space. These 3-D interactions are thought to allow proteins that bind DNA to regulate the activity of genes that are distant from where they are binding.

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